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Allopurinol has previously been shown to decrease levels of C-reactive protein, slow down progression of renal disease, and decrease hospitalization and CV risk in CKD sufferers, write the researchers. ‘If such beneficial results are also obvious in hypertensive subjects with lower GFR, then the CV threat of these subjects might be suppressed with allopurinol.’ Licensed from medwireNews with authorization from Springer Health care Ltd. All rights reserved. Neither of the parties endorse or recommend any commercial products, services, or equipment.. Allopurinol might improve CV outcomes in kidney disease By Sally Robertson, medwireNews Reporter The xanthine oxidase inhibitor allopurinol is apparently beneficial in preventing cardiovascular morbidity and all-cause mortality in patients with hypertensive nephropathy, display findings from a Japanese study.