Total ABCB1 polymorphisms were with Parkinsons disease with Parkinsons disease risk.
These results support the hypothesis of gene x pesticide interactions in Parkinson ‘s disease, Archives of Neurology 2013;. 67[ 6]:739 – 745th.. Total ABCB1 polymorphisms were with Parkinson’s disease with Parkinson’s disease risk. But among 101 men with Parkinson’s disease and 234 control subjects, was the relationship between organochlorine insecticide exposure and Parkinson’s disease approximately 3.5 times stronger in men. Two versions alleles , compared to those that are not carried out backing Based on a biological hypothesis, we show that organochlorine insecticides can ABCB1 interact in determining the risk of Parkinson’s disease, the authors conclude.
The gene may encode the ABCB1 preparing compounds essential to this process.
Fabien Dutheil, the Universit? Paris Descartes, Assistance Publique – H? Pitaux de Paris, and colleagues studied 207 patients with Parkinson’s disease and 482 controls. Participants were assessed to detect two known ABCB1 polymorphisms and classified as never users, users for gardening and professional users of pesticides. For business users, gathered detailed information on lifelong pesticide use.. In most casesticide exposure interact to increase men’s risk for Parkinson’s diseaseGenetic mutations and workplace exposure common to several insecticides appear to be associated with an increased risk for Parkinson’s disease in men in connection, according to a report in the June issue of the Archives of Neurology, one of the JAMA / Archives journals. (more…)