Joep de Ligt.

Joep de Ligt, M.Sc., Marjolein H . Willemsen, M.D., Bregje W.M. Van Bon, M.D., Ph.D., Tjitske Kleefstra, M.D., Ph.D., Helger G. Yntema, Ph.D., Thessa Kroes, B.Sc., Anneke T. Vulto-van Silfhout, M.D., David A. Koolen, M.D., Ph.D., Petra de Vries, B.Sc., Christian Gilissen, Ph.D., Marisol del Rosario, B.Sc., Alexander Hoischen, Ph.D., Hans Scheffer, Ph.D., Bert B.A. De Vries, M.D., Ph.D., Han G. Brunner, M.D., Ph.D., Joris A. Veltman, Ph.D., and Lisenka E.L.M. Vissers, Ph.D.: Diagnostic Exome Sequencing in People with Severe Intellectual Disability Severe intellectual disability, which is referred to as cognitive impairment or mental retardation also, affects 0 approximately.5 percent of the populace in Western countries1,2 and represents a significant health burden.

Although the overall threat of rupture can end up being suffering from this selection bias, the analysis of individual risk factors should not be influenced substantially. The chance of rupture for aneurysms that were smaller than 5 mm in our study is very similar to the threat of rupture of single aneurysms in the Small Unruptured Intracranial Aneurysm Verification study ,8 where no surgical intervention was allowed during the follow-up period. Therefore, we believe that the impact of selection bias on our analysis of individual risk elements should be acceptably small. Although most patients were successfully and consecutively enrolled based on the study protocol, not all patients who were eligible were enrolled. The number and features of the unregistered individuals were not documented, and we were therefore unable to compare the features of the individuals who were incorporated with those of the individuals who weren’t included, to assess potential biases in selecting patients.