Generalized estimating equations7 had been used to account for within-hospital clustering, since individuals at the same hospital may have identical disease profiles. The Wald chi-square test was used to find out significant predictors of obstructive coronary artery disease. To comprehend the relative value of the elements in predicting obstructive coronary artery disease, we constructed four separate versions; we started with a model for predicting risk if no symptoms had been present, as assessed with the use of the Framingham risk score alone, and added in to the model other clinical factors then, accompanied by documented symptoms, and finally the outcomes of noninvasive testing. The predictive value of each model is normally represented by the C-statistic.Angiogenesis is known to have an important role in breast tumor also, and although previous research combining chemotherapy with the antiangiogenesis drug bevacizumab delayed disease progression, they have not really extended overall survival. Furthermore to directly blocking the HER2-managed growth pathway, anti-HER2 drugs also contribute to suppression of tumor-associated blood vessels. Previous research in Jain's lab suggested that the proangiogenic aspect VEGF might overcome the antiangiogenic ramifications of anti-HER2 drugs.