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Also, age at medical diagnosis, tumor size, tumor grade, and axillary treatment or no axillary treatment were associated with the risk of events . In the node-positive, adjuvant-therapy cohort, the subgroup of patients who received chemotherapy only was small , which limited statistical analysis according to treatment, though patients who received combined chemotherapy and endocrine treatment appeared to have the largest benefit, as compared with patients in the node-positive, no-adjuvant-therapy cohort . The outcome according to the kind of adjuvant systemic therapy are proven in Table 4 and Table 5 in the Supplementary Appendix.