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‘PENTAX Medical is very happy to support the AGA Institute in its function to promote creativity in gastroenterology,’ stated Len Farris, vice president of advertising, Americas, PENTAX Medical. ‘By investing in the AGA Institute, we are putting innovation in the tactile hands of GI clinicians who are in the forefront of battling digestive diseases. We look forward to the technological discoveries that will result from this collaboration.’..A detailed description of the methods used is offered in the Supplementary Appendix, obtainable with the full text of the article at NEJM.org. Results INF2 Mutations Heterozygous INF2 mutations were detected in 12 of the 16 index patients . Nine different mutations were determined: eight missense mutations and one in-framework deletion of three amino acids. All were brand-new mutations located in exons 2 and 3, which encode the DID domain , and all caused nonconservative changes in conserved amino acids highly.